Accepted
at 1:45 a.m. Jun, 14, 2025
by
pkaps01
Author:
aidan888
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- Translation of mRNA to proteins begins in the cytosol. From there, proteins meant for cellular use travel to their intracellular destination.
- However, proteins intended for the secretory pathway have N-terminal signal sequences that causes them to be transferred to the rough endoplasmic reticulum (RER)
- In the RER, post-translational modifications such as glycosylation, disulfide bond formation, phosphorylation, and protein cleavage can occur.
- The RER then packages proteins into vesicles and sends them to the golgi aparatus for further processing (retrograde processing)
- Finally, the golgi apparatus packages proteins into secretory vesicles which fuse with the plasma membrane and releases the contents outside of the cell
Photo credit: Giovanna De Chiara, Maria Elena Marcocci, Rossella Sgarbanti, Livia Civitelli, Cristian Ripoli, Roberto Piacentini, Enrico Garaci, Claudio Grassi, Anna Teresa Palamara, CC BY 2.5, via Wikimedia Commons
Golgi apparatus: general structure and role in packaging and secretion - Jack Westin
- However, proteins intended for the secretory pathway have N-terminal signal sequences that causes them to be transferred to the rough endoplasmic reticulum (RER)
- In the RER, post-translational modifications such as glycosylation, disulfide bond formation, phosphorylation, and protein cleavage can occur.
- The RER then packages proteins into vesicles and sends them to the golgi aparatus for further processing (retrograde processing)
- Finally, the golgi apparatus packages proteins into secretory vesicles which fuse with the plasma membrane and releases the contents outside of the cell
Photo credit: Giovanna De Chiara, Maria Elena Marcocci, Rossella Sgarbanti, Livia Civitelli, Cristian Ripoli, Roberto Piacentini, Enrico Garaci, Claudio Grassi, Anna Teresa Palamara, CC BY 2.5, via Wikimedia Commons
Golgi apparatus: general structure and role in packaging and secretion - Jack Westin
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