Created at 10:17 p.m. Jun, 09, 2025
Author:
neurostormer
Type of change:
Updated content
Rationale for change
The issue in Dandy-Walker malformation is that there is either agenesis or hypoplasia of the cerebellar vermis, which causes dilation of the 4th ventricle (which shouldn't be closed normally, so not sure where failure of 4th ventricle to close came from?)
Source: First aid 2024 page 502
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- Disruption of HOX gene expression in rhombencephalon disrupts mesenchymal development in the metencephalon

Photo Credit: Helmut Januschka, CC BY-SA 3.0, via Wikimedia Commons (left); Hellerhoff, CC BY-SA 3.0, via Wikimedia Commons (right); the supplementary image with overlays of the relevant areas was adapted from the image mentioned previously, licensed under CC BY-SA 3.0
- This disrupts angiogenesis, causing choroid plexus to undergo excessive development
- Overgrown choroid plexus disrupts microglia with phagocytic activity required for midline formation of the vermis → agenesis of the vermis

Photo Credit: Helmut Januschka, CC BY-SA 3.0, via Wikimedia Commons (left); Hellerhoff, CC BY-SA 3.0, via Wikimedia Commons (right); the supplementary image with overlays of the relevant areas was adapted from the image mentioned previously, licensed under CC BY-SA 3.0
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