Rejected
at 5:27 p.m. Oct, 31, 2023 ]
by
Alex
Author:
shmuelsash
Type of change:
Content error
Rationale for change
Not really sure what this card was meant to ask but here are soem relevant facts:
CD-40 in T cells activate CD40 receptor on B cells to class switch
ALSO
B7 is a ligand on B cells which activates CD28 on T cells to secrete cytokines
ALSO
Macrophages are a type of APC (antigen presenting cell) that (like a B cell which is a type of APC) has B7 which interacts with CD28 on a T cell
Rejection reason
unresolved after months, can revisit if necessary, appreciate recs
Current
Suggested
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Extra
- As this interaction causes the APC to express T-cell costimulatory signals (B7)
- Recall B7/CD28 interaction involved in T cell activation
- CD40/CD40L interaction also enhances MHC II expression on APC
- B7 also known as CD80/86
- Recall B7/CD28 interaction involved in T cell activation
- CD40/CD40L interaction also enhances MHC II expression on APC
- B7 also known as CD80/86
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