Accepted
at 5:26 p.m. Oct, 31, 2023
by
Alex
Author:
shmuelsash
Type of change:
Spelling/Grammar
Rationale for change
clarified qs - i kept thinking it was asking what happens in terms of the complement proteins
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Photo credit: James Heilman, MD, CC BY-SA 3.0, via Wikimedia Commons
Angioedema of the lips:

Image(s) licensed by DermNet and used with permission, CC-BY-NC-ND 3.0 NZ

- C1 inhibitor (AKA C1-esterase inhibitor) normally inhibits kallikrein, which is responsible for conversion of HMWK to bradykinin
- Deficiency leads to high levels of serum bradykinin → episodes of swelling and edema
- Can treat with icatibant (bradykinin B2 receptor antagonist), C1-inhibitor concentrate, or ecallantide (kallikrein inhibitor)

Photo credit: James Heilman, MD, CC BY-SA 3.0, via Wikimedia Commons
Angioedema of the lips:

Image(s) licensed by DermNet and used with permission, CC-BY-NC-ND 3.0 NZ

Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid




Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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OME
Additional Resources

characterized by rapid-onset edema of the face, genitals, limbs, larynx, and intestines without urticaria (helps distinguish hereditary angioedema from type 1 hypersensitivity reactions); treatment options include with fresh frozen plasma (contains C1 inhibitor), icatibant (bradykinin antagonist), and/or ecallantide (kallikrein inhibitor)

characterized by rapid-onset edema of the face, genitals, limbs, larynx, and intestines without urticaria (helps distinguish hereditary angioedema from type 1 hypersensitivity reactions); treatment options include with fresh frozen plasma (contains C1 inhibitor), icatibant (bradykinin antagonist), and/or ecallantide (kallikrein inhibitor)
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