Accepted at 5:26 p.m. Oct, 31, 2023 by Alex
Author: shmuelsash
Related Note: 1487727789545
Rationale for change

clarified qs - i kept thinking it was asking what happens in terms of the complement proteins

Text Text
Extra
- C1 inhibitor (AKA C1-esterase inhibitor) normally inhibits kallikrein, which is responsible for conversion of HMWK to bradykinin

- Deficiency leads to high levels of serum bradykinin → episodes of swelling and edema

- Can treat with icatibant (bradykinin B2 receptor antagonist), C1-inhibitor concentrate, or ecallantide (kallikrein inhibitor)


Photo credit: James Heilman, MD, CC BY-SA 3.0, via Wikimedia Commons
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy

Watch Complement System Disorders
Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - Complement Disorders
OME

Additional Resources

characterized by rapid-onset edema of the face, genitals, limbs, larynx, and intestines without urticaria (helps distinguish hereditary angioedema from type 1 hypersensitivity reactions); treatment options include with fresh frozen plasma (contains C1 inhibitor), icatibant (bradykinin antagonist), and/or ecallantide (kallikrein inhibitor)
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#AK_Step1_v12::#FirstAid::02_Immunology::03_Immune_Responses::05_Complement_disorders #AK_Step2_v12::!Shelf::FM::no_dupes #AK_Step2_v12::Original_decks::Zanki_Step_2::Peds::ENT,_Allergy,_&_Immunology #AK_Step2_v12::#AMBOSS::9J0NwS #AK_Step2_v12::Original_decks::Dorian::peds::uw::ent_allergy_immuno #PANCE::EOR::Family_med #AK_Step2_v12::#Resources_by_rotation::Peds::ome::immunodeficiency #AK_Step2_v12::#OME::03_Pediatrics::25_Immunodeficiency #AK_Step2_v12::Original_decks::Dorian::peds::ome::immunodeficiency #AK_Step1_v12::#UWorld::COMLEX::24723 #AK_Step2_v12::#Resources_by_rotation::FM::ome::peds::allergies #AK_Step1_v12::#Pixorize::02_Immunology::02_Complement::02_Classical_Complement_Pathway #AK_Step1_v12::#Physeo::08_Immunology::01_Immunology::04_Kinin #AK_Step2_v12::#Resources_by_rotation::Peds::uworld::ent_allergy_immunology::ent_allergy_immunology_dorian #AK_Step2_v12::#OME::03_Pediatrics::14_Allergies #AK_Step2_v12::Original_decks::Dorian::peds::ome::allergies #AK_Step1_v12::#Bootcamp::Immunology::08_Complement::03_Complement_Disorders #AK_Step2_v12::!Shelf::Peds::no_dupes !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Immunology+General-Pathology::Pathoma-Chapter-2-(Inflammation) #AK_Step1_v12::#UWorld::Step::1612 #PANCE::DERM::papulosquamous_disorders #AK_Step1_v12::^Other::^FA_Updates::FA2018 AnkiHub_ImageReady::Extra #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Immunology_+_General_Pathology::Pathoma_Chapter_2_(Inflammation) #AK_Step1_v12::#OME::Clinical::Pediatrics::General_Pediatrics::Allergic_Reactions #AK_Step1_v12::^Other::^HighYield::3-HighYield-temporary #AK_Step2_v12::#Resources_by_rotation::Peds::uworld::ent_allergy_immunology::ent_allergy_immunology_zanki #AK_Step1_v12::#Physeo::08_Immunology::01_Immunology::05_Complement #AK_Step2_v12::Original_decks::Dorian::peds::nbme #AK_Step1_v12::#Pathoma::02_Inflammation::03_Primary_Immunodeficiency #AK_Step2_v12::#UWorld::COMLEX::28581 #AK_Step1_v12::#NBME::21 !AK_UpdateTags::^temporary::ImageFix::10::done #AK_Step2_v12::#Resources_by_rotation::Peds::ome::allergies AnkiHub_ImageReady::Text #AK_Step2_v12::#UWorld::Step::2769 #AK_Step2_v12::#Resources_by_rotation::Peds::nbme::form_3 #AK_Step2_v12::#OME::03_Pediatrics::01_General_Pediatrics::02_Allergic_Reactions #AK_Step1_v12::#FirstAid::02_Immunology::03_Immune_Responses::05_Complement_disorders::02_Complement_regulatory_protein_deficiencies::*C1_Esterase_Inhibitor_Deficiency #AK_Step2_v12::Original_decks::Dorian::fam::ome::peds::allergies #AK_Step1_v12::#AMBOSS::lS0v-2 #AK_Step2_v12::#AMBOSS::lS0v-2 #AK_Step1_v12::#SketchyPath::11_Immunology::02_Immunodeficiency::03_Complement_System_Disorders #AK_Step1_v12::^Other::^EXPN::BGedit #AK_Step1_v12::#UWorld::Step::20747 #AK_Step1_v12::#B&B::11_Hematology::01_Hemostasis::01_Coagulation::Extra