Rejected
at 2:31 a.m. Nov, 01, 2023 ]
by
dollajas
Author:
thomas.holmes
Type of change:
Updated Tags
Rationale for change
Content already covered (card ID: 3a856062-e0d4-4785-ab7f-89d9737dc0ae)
Rejection reason
resolved
No changes in fields
Text
For life-threatening malaria, use {{c2::IV artesunate (1st line)}} or {{c1::quinidine*}}
Extra
*Quinidine is used in the United States, quinine is used elsewhere
- Quinidine is a class 1A anti-arrhythmic drug that can target the erythrocytic stage of Plasmodium species
- Quinine works similarly to chloroquine, by inhibiting heme polymerization causing lysis of cell membranes
- Artesunate generates ROS which inhibits synthesis of proteins and nucleic acids
- If artesunate is not immediately available, begin interim oral treatment (e.g., artemether-lumefantrine, atovaquone-proguanil, quinidine, or mefloquine)
- Discontinue oral agent and administer IV artesunate as soon as it becomes available
- Quinidine is a class 1A anti-arrhythmic drug that can target the erythrocytic stage of Plasmodium species
- Quinine works similarly to chloroquine, by inhibiting heme polymerization causing lysis of cell membranes
- Artesunate generates ROS which inhibits synthesis of proteins and nucleic acids
- If artesunate is not immediately available, begin interim oral treatment (e.g., artemether-lumefantrine, atovaquone-proguanil, quinidine, or mefloquine)
- Discontinue oral agent and administer IV artesunate as soon as it becomes available
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Watch associated Bootcamp video - Systemic Protozoa: Plasmodium
Watch associated Bootcamp video - Antiparasitics: Chloroquine-Resistant and Exo-Erythrocytic Antimalarials
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