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What is the management of lobular carcinoma in situ (LCIS) discovered on core needle biopsy?
Low risk LCIS: {{c1::surveillance ± tamoxifen}}
High risk LCIS: {{c1::tamoxifen ± prophylactic bilateral mastectomy}}
Nonclassic LCIS: {{c1::excisional biopsy}}
Low risk LCIS: {{c1::surveillance ± tamoxifen}}
High risk LCIS: {{c1::tamoxifen ± prophylactic bilateral mastectomy}}
Nonclassic LCIS: {{c1::excisional biopsy}}
Extra
- LCIS is always ER (+) → SERMs are ideal for preventing disease progression
- Even with high risk LCIS, mastectomy is usually reserved for very high risk patients (known genetic mutation, compelling family history, prior radiation to chest wall)
- Classic LCIS (whether low or high risk) generally does not require excisional biopsy unless pathologic and radiologic findings are discordant; however, nonclassic LCIS always requires excisional biopsy to rule out invasive cancer
- vs. DCIS, which requires lumpectomy to negative margin
DCIS with calcification:
Photo credit: © Lunar Caustic, all rights reserved, via Flickr. Used with permission
Photo credit: © Lunar Caustic, all rights reserved, via Flickr. Used with permission
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
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Sketchy
Watch Breast Cancer
Watch Breast Cancer
Sketchy 2
Watch Simple Mastectomy Overview
Watch Simple Mastectomy Overview
Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - Cellular Injury and Neoplasia: Cell Cycle Independent Drug Targets
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Additional Resources
Emma Holiday: