Created at 1:07 a.m. May, 10, 2025
Author:
vnagendra
Type of change:
Updated content
Rationale for change
Pancreatitis induces activation of trypsinOGEN into trypsin. Trypsin is not directly being activated by the disease, its activation is indirect.
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* Injury to parenchyma or ductal obstruction (impairs blood flow) causes Acinar cell dysfunction, which causes intra-acinar trypsinogen activation→ Activation/release of other pancreatic autodigestive enzymes


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