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A regulatory enzyme is any enzyme whose activity can be modulated to control a pathway's rate.
The rate-limiting enzyme specifically catalyzes the single slowest step, which acts as a bottleneck and determines the overall speed of the entire pathway. For this reason, the rate-limiting step is a key target for regulation.
In the citric acid cycle, isocitrate dehydrogenase is the rate-limiting enzyme.

A regulatory enzyme is any enzyme whose activity can be modulated to control a pathway's rate.
The rate-limiting enzyme specifically catalyzes the single slowest step, which acts as a bottleneck and determines the overall speed of the entire pathway. For this reason, the rate-limiting step is a key target for regulation.
In the citric acid cycle, isocitrate dehydrogenase is the rate-limiting enzyme.
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