Created at 7:59 p.m. Apr, 22, 2025
Author:
curby29
Type of change:
Updated content
Rationale for change
Updated to match most recent sketch, now 1.3, added Neonatal Abstinence Syndrome and Suboxone. The rest looked pretty much the same.
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Extra Q
Which opioid receptor mediates most of the clinical and adverse effects of opiates?
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μ
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What ion channels are affected secondary to μ-opiate receptor stimulation?
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(1) Open post-synaptic K+ channels
(2) Close pre-synaptic Ca2+ channels
(Stimulation of κ receptor in dorsal horn also ⇒ ↓ Substance P)
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MOA: Tramadol
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(1) Weak μ-agonist
(2) NET/SERT Inhibitor
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MOA: Loperamide
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Locally active μ agonist
(Does not cross BBB ⇒ Only slows GI motility)
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Indication: Diphenoxylate
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Diarrhea
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Adverse Effects (6) : Opiates
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(1) CNS depression
(2) Respiratory depression
(3) Miosis
(4) Constipation
(5) Biliary colic
(6) Opiate induced hyperalgesia
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Name 2 effects of opiates to which tolerance does not develop
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(1) Miosis
(2) Constipation
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What phrase summarizes the symptoms of opiate withdrawal?
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"Anxious, hot, and moist"
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Name a long acting full μ-agonist used to attenuate withdrawal symptoms
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Methadone
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Name a long acting partial μ-agonist used to attenuate withdrawal symptoms
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Buprenorphine
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What μ-opioid antagonist is used to reverse acute opioid toxicity?
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Naloxone
(Naloxone is a shorter word than Naltrexone ∴ shorter acting)
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Which μ-opioid antagonist is used to help maintain abstinence in heroin addicts?
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Naltrexone
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Indications (3) : Naltrexone (unrelated to heroin)
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(1) Alcohol addiction
(2) Nicotine addiction
(3) Weight loss
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