added tag for nbme 12 question, directly answers the question:
A 78-year-old woman comes to the physician because of a 2-week history of mild right knee pain, especially when she walks up stairs. During this time, she also has had stiffness in her knee in the morning. She enjoys walking around her neighborhood but has been unable to walk because of the pain. She has gastroesophageal reflux disease and takes omeprazole occasionally. Vital signs are within normal limits. On examination, active and passive range of motion of the right knee is full; there is moderate crepitus and no effusion. Which of the following is the most appropriate pharmacotherapy?
Answer: Acetaminophen
Educational Objective: Osteoarthritis (OA) is a common condition leading to joint pain in older patients. Other medications include nonsteroidal anti-inflammatory drugs (NSAIDs), although these should be avoided in patients with a history of gastrointestinal bleeding or chronic kidney disease.