Accepted
at 8:04 p.m. Jun, 10, 2025
by
Ahmed7
Author:
dsheth1
Rationale for change
Question 8 Block 3
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Text
What pharyngeal arch abnormality is characterized by cleft palate, airway obstruction, micrognathia, and glossoptosis?
{{c1::Pierre Robin sequence}}
Extra
- This is caused by a defect in the first pharyngeal arch


Photo credit: Morice A, Soupre V, Mitanchez D, Renault F, Fauroux B, Marlin S, Leboulanger N, Kadlub N, Vazquez M-P, Picard A and Abadie V (2018) Severity of Retrognathia and Glossoptosis Does Not Predict Respiratory and Feeding Disorders in Pierre Robin Sequence. Front. Pediatr. 6:351. doi: 10.3389/fped.2018.00351
- A sequence occurs when a single developmental defect causes a cascade of additional malformations. This is highlighted below:
- Micrognathia (hypoplasia of the mandibular prominence) → glossoptosis (posterior displacement of the tongue into the pharynx) → cleft palate
- Micrognathia (hypoplasia of the mandibular prominence) → glossoptosis (posterior displacement of the tongue into the pharynx) → cleft palate
- This is caused by a defect in the first pharyngeal arch


Photo credit: Morice A, Soupre V, Mitanchez D, Renault F, Fauroux B, Marlin S, Leboulanger N, Kadlub N, Vazquez M-P, Picard A and Abadie V (2018) Severity of Retrognathia and Glossoptosis Does Not Predict Respiratory and Feeding Disorders in Pierre Robin Sequence. Front. Pediatr. 6:351. doi: 10.3389/fped.2018.00351
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Sketchy
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Bootcamp
Watch associated Bootcamp video - Fetal Development: Pharyngeal Apparatus
Watch associated Bootcamp video - Oral Cavity : Pharyngeal Arch Derivatives of Mastication
Watch associated Bootcamp video - Oral Cavity : Pharyngeal Arch Derivatives of Mastication
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