Accepted at 2:28 p.m. Apr, 17, 2025 by Dam_Doc
Author: daltoncaples
Co-authors: Dam_Doc
Related Note: 1554094708656
Rationale for change

Source: UWorld Question Bank
QID: 403358

Rationale:
Passage Excerpt: The passage states that PC5 processes itself by autocleavage when it arrives at the cell surface and that it does not act on other proteins until after autocleavage occurs.


Question:
Prior to reaching the cell surface, PC5 is:
A. an apoenzyme
B. a coenzyme
C. a holoenzyme
D. a zymogen

Answer:
D. a zymogen

Explanation:
I'm not sure how you feel about this one — either way, I think it's fine. The way I revised the card may be less broad, but I believe it provides a clearer and more focused explanation. PC5 is an enzyme that must be cleaved to become active. Although it's technically a precursor, I don’t think that label alone fully captures what a zymogen is.

That said, I think this either version still conveys the key concept.

Please let me know if you need any additional information.

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Changed Tags
#AK_MCAT_v2::$Errata::Text_Edited
#AK_MCAT_v2::#AAMC::Concepts::B/B::Foundational_Concept_01::1A-Proteins_and_Amino_Acids !AK_UpdateTags::^temporary::ImageFix_MCAT::02::done #AK_MCAT_v2::#AAMC::Concepts::C/P::Foundational_Concept_05::5E-Principles_of_Chemical_Thermodynamics_and_Kinetics #AK_MCAT_v2::#UWorld_Books::Biochemistry::Ch-04-Enzyme_Activity #AK_MCAT_v2::#UWorld::403358 #AK_MCAT_v2::#UWorld_Books::Biochemistry::Ch-06-Feedback_Regulation AnkiHub_Subdeck::AnKing-MCAT::Biochemistry #AK_MCAT_v2::#KhanAcademy::Biochemistry::Biomolecules::Enzymes #AK_MCAT_v2::AK_Original_Decks::MileDown::Biochemistry::Enzymes #AK_MCAT_v2::#Kaplan::Biochemistry::Ch-02-Enzymes