Created at 4:52 p.m. Apr, 09, 2025
Author:
hisham242
Type of change:
Updated content
Rationale for change
According to AMBOSS
" Cobalamin is released from ingested proteins by pepsin and binds to the glycoprotein haptocorrin (R-protein), which protects it from gastric acid."
Source: AMBOSS - https://next.amboss.com/us/article/Ao0ReS
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Thus allowing vitamin B12 to be bound by R-binder (AKA haptocorrin or cobalophilin) until duodenum where it binds intrinsic factor (absorbed in the terminal ileum)
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Pathoma
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Sketchy 2
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Picmonic
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Bootcamp
Watch associated Bootcamp video - Macrocytic Anemia: Cobalamin (Vitamin B12) Deficiency
Watch associated Bootcamp video - Stomach : Vitamin B12 Absorption
Watch associated Bootcamp video - Stomach : Vitamin B12 Absorption
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