Created at 7:09 p.m. Apr, 01, 2025
Author:
curby29
Type of change:
Updated content
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Updated Sketchy; 1.1 is only Digoxin now; 1.3 is a new video w/ milrinone, nesiritide, ivabradine, and sacubitril/valsartan with BNP explanation
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What plant is Digoxin derived from?
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Foxglove plant
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MOA: Cardiac glycosides
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Inhibit Na+/K+ ATPase
(⇒ ↓ Ca2+ efflux due to inhibition of Na+/Ca2+ exchanger)
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Indications (2) : Digoxin
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(1) Heart failure
(2) Atrial arrhythmias
(Inhibition of neuronal Na+,K+ ATPase ⇒ Depolarization of ANS efferents ⇒ ↑ PNS on nodes (↓ HR) and ↑ SNS on ventricles (↑ Contractility) )
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Name 5 signs of Digoxin poisoning
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(1) Hyperkalemia
(2) ⇒ Arrhythmias
(3) Bradycardia
(4) Nausea/Vomiting
(5) Xanthopsia
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What effect does Digoxin have on EKG?
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"Scooped" concave ST segments
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How does Digoxin reduce heart rate?
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↑ PNS on SA/AV
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What electrolyte abnormality exacerbates Digoxin toxicity?
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Hypokalemia
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How is Digoxin eliminated from the body?
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Renal clearance
(Note: Digoxin has a huge Vd as its concentration is buffered by the ubiquitous Na+,K+-ATPase)
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Treatment: Digoxin toxicity
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anti-Digoxin Fabs
(Mg2+ also helpful)
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MOA: Milrinone
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Inhibits phosphodiesterase
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MOA: Nesiritide
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Analog of BNP
(⇒ Diuresis and arteriolar/venous dilation)
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Contraindication - Cardiac Origin: Digoxin
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Heart block
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Entire Sketch
1.1 - Digoxin, milrinone, nesiritide 
Sketchy Extra
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