Created at 6:10 p.m. Mar, 22, 2025
Author:
mjtodd
Type of change:
Updated content
Rationale for change
If inhibition of 11-beta-hydroxylase by metyrapone, cortisol will be reduced driving ACTH production in primary adrenal insufficiency or decreased ACTH in secondary/tertiary insufficiency.
Source: Other - N/A
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{{c1::Metyrapone::Drug}} inhibits glucocorticoid biosynthesis via inhibition of the enzyme {{c2::11β-hydroxylase}}
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Watch Hypothalamic & Pituitary Dysfunction Clinical Manifestations



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* administration → decreased cortisol → loss of negative feedback on anterior pituitary → increased ACTH secretion



Watch Hypothalamic & Pituitary Dysfunction Clinical Manifestations



Watch Cushings Syndrome
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