Rejected at: Apr, 01, 2024
3:31 p.m.
Author:
jiffypeople
Related Deck:
1659122273009
Rejected
Rationale for new note
UWorld Step 2 QID: 15401; no Anking card currently talks about neprilysin inhibitors increasing bradykinin. Also Ankihub needs to update post-MI/HFrEF therapy to reflect Intresto preference (reference: UpToDate articles for HFrEF and MI medical management)
Rejection reason
working on this concept with another open suggestion
Text
new-onset facial puffiness in a HFrEF patient with no peripheral edema taking sacubitril-valsartan is concerning for {{c1::angioedema}}
Text
new-onset facial puffiness in a HFrEF patient with <u>no</u> peripheral edema taking sacubitril-valsartan is concerning for {{c1::angioedema}}
Extra
ARBs do NOT cause angioedema, but sacubitril (neprilysin inhibitor) DOES through same mechanism as ACEi (increased bradykinin)
-note Intresto (sacubitril-valsartan) is preferred therapy for HFrEF/MI (over ACEi/ARBs)
-this pt should be sent to ED c/f rapid progression to airway obstruction
-note Intresto (sacubitril-valsartan) is preferred therapy for HFrEF/MI (over ACEi/ARBs)
-this pt should be sent to ED c/f rapid progression to airway obstruction
Extra
ARBs do NOT cause angioedema, but sacubitril (neprilysin inhibitor) DOES through same mechanism as ACEi (increased bradykinin)<br>-note <u>Intresto (sacubitril-valsartan)</u> is <u>preferred</u> therapy for HFrEF/MI (over ACEi/ARBs)<br>-this pt should be <u>sent to ED</u> c/f rapid progression to <u>airway obstruction</u>
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