Created at 6:26 p.m. Mar, 08, 2025
Author: Arcamenel
Related Note: 1695292646586 1
Rationale for change

added dermnet photos, links submitted

DermNet DermNet
Text
Pathogenesis of melanoma:

{{c3::GNAQ/GNA11}} gene mutations → {{c1::uveal}} melanoma, {{c2::blue}} nevi, and Nevus of Ota
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Dermatographix

Melanoma Risk Factors and Pathogenesis (DermatoGraphix)
Inherited Mutations
•Family cycling: Inherited CDKN2A mutations (FAMMM syndrome)
•14-year-old barfing: p14 ARF is a protein product
•16-year-old: p16 is another protein product

BRAF Mutation
•Raft: BRAF
•V600 engine: V600E mutation is most common
•Roof protecting from sun: Associated with non-chronically sun-exposed sites
•Floats superficially on top of the river: Associated with superficial spreading melanoma

NRAS Mutation
•RATS: NRAS
•Tanning in the sun: Associated with chronically sun-exposed sites
•Eating a nodule of cheese: Associated with nodular melanoma
•Nodular rocket launches vertically: Nodular melanoma has a vertical growth phase

Cyclin D1 and C-KIT Mutations
•D1 cycler eating a KIT Kat: Cyclin D1 (aka CCDN1) and C-KIT mutations
•KitKat bar melted from sun exposure: Both CCDN1 and C-KIT are associated with chronically sun-damaged (CSD) sites
•Eating KitKat with mouth: Both are also associated with mucosal melanomas
•Holding it in hand: Both are associated with acral melanoma

GNAQ and GNA11 Mutations
•GINA eating a GNAQ SNAQ ("g-nack snack"): GNA11 and GNAQ mutation
•Blue packaging: Associated with blue nevi
•Using an eyedrop: Uveal melanoma association

BAP-1 Loss of Function Mutation
•BAT: BAP-1 loss of function mutation
•Getting bitten: Strongly associated with a worse prognosis
•Bat grabbing eye: BAP-1 mutation -> Increased risk of uveal melanoma
•Blue crab: Increased risk of malignant cellular blue nevus
•Bat spitting: Epithelioid spitzoid nevi (aka Bapomas)

Associated Internal Malignancies
•Bat atop a lung-shaped tree: Mesothelioma
•Kidney growing out of trunk: Renal cell carcinoma
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#Dermki::Alikhan::06_Neoplastic_Derm::06.03_Melanocytic_neoplasms #Dermki::DermatoGraphix::GenDerm::Melanoma::Risk_Factors_&_Pathogenesis AnkiHub_Subdeck::Dermki::06_Neoplastic_Dermatology