Created at 6:09 p.m. Feb, 28, 2025
Author: mayomo28
Co-authors: andrewmathias8
Related Note: 1482959705416 1
Rationale for change

I'm aware AMBOSS says "Individuals with Lynch syndrome have a 70–80% lifetime risk of developing CRC". Their source (https://qxmd.com/r/8550246) is published in 1995 and likely out of date. More recent research (published 2020) demonstrates significantly lower CRC lifetime penetrance (by age 70). To quote the meta-analysis: "At age 70 years, for male and female carriers, respectively, risks for MLH1 were 43.9% (95% confidence interval [CI] = 39.6% to 46.6%) and 37.3% (95% CI = 32.2% to 40.2%), for MSH2 were 53.9% (95% CI = 49.0% to 56.3%) and 38.6% (95% CI = 34.1% to 42.0%), and for MSH6 were 12.0% (95% CI = 2.4% to 24.6%) and 12.3% (95% CI = 3.5% to 23.2%)."
Source: AMBOSS - https://pmc.ncbi.nlm.nih.gov/articles/PMC7476651/

Text Text
Extra
Lecture Notes
Empty field
Missed Questions
Empty field
Pathoma
Empty field
Boards and Beyond
Empty field
First Aid
Sketchy
Sketchy 2
Sketchy Extra
Empty field
Picmonic
Empty field
Pixorize
Physeo
Empty field
Bootcamp
Empty field
OME
Additional Resources
One by one
Empty field
#PANCE::EOR::Family_med #AK_Step1_v12::#Physeo::11_Pathology::06_Gastrointestinal_Pathology::14_Other_Liver_Conditions #AK_Step1_v12::#FirstAid::09_Gastrointestinal::04_Pathology::28_Lynch_syndrome #AK_Step1_v12::#AMBOSS::JA0ski #PANCE::GI::colorectal_disorders #AK_Step1_v12::#AMBOSS::l6avOl #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::03_Gastrointestinal::01_Digestion_&_Absorption::12_Neoplasia_of_Large_Intestine #AK_Step1_v12::#B&B::22_Repro::04_Ovary::02_Ovarian_Epithelial_Tumors::Extra #AK_Step1_v12::#Pathoma::10_GI::09_Colorectal_Carcinoma #AK_Step1_v12::#AMBOSS::gA0FQi #AK_Step1_v12::#Low/HighYield::1-HighYield #AK_Step2_v12::#OME::01_Medicine::03_Gastroenterology::11_Colon_Cancer #AK_Step1_v12::#UWorld::COMLEX::23542 #AK_Step1_v12::#B&B::10_GI::03_Clinical_Gastroenterology::14_Colon_Cancer::Extra #AK_Step2_v12::#AMBOSS::l6avOl #PANCE::EOR::IM #AK_Other::Only_Step_1&2_Overlap #AK_Step1_v12::#Pixorize::01_Biochemistry::10_DNA_Repair::01_Lynch_Syndrome #AK_Step2_v12::#AMBOSS::Fs0g9h #AK_Step2_v12::#SketchySurgery::06_Lessons_from_the_OR::08_Colectomy_Overview #AK_Step1_v12::#UWorld::Step::429 #AK_Step1_v12::#B&B::22_Repro::03_Vagina_Cervix_Uterus::05_Endometrial_Cancer::Extra #AK_Step1_v12::#Physeo::11_Pathology::06_Gastrointestinal_Pathology::09_Colon_Polyps_Carcinoma #AK_Step2_v12::#SketchyIM::10_Gastroenterology::03_Colon_Disorders::06_Colorectal_Cancer:_Carcinogenesis #AK_Step1_v12::#OME::04_Organ_Systems::03_Gastrointestinal::01_Digestion_&_Absorption::12_Neoplasia_of_Large_Intestine #AK_Step2_v12::#Resources_by_rotation::IM::ome::gi::colon_cancer #AK_Step1_v12::#SketchyPath::05_GI::03_Colorectal_&_Anal_Disorders::03_Colorectal_Polyps_&_Cancer #PANCE::EOR::Surgery #AK_Step2_v12::#B&B::06_GI::04_Intestines::01_Colon_Cancer::Extra #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_GI::GI_Pathology #AK_Step1_v12::^Systems::GI::pathology