Accepted at 6:50 p.m. Sep, 14, 2025 by mitchelnelson
Author: lukewhelchel
Co-authors: Ahmed7 , andrewmathias8
Related Note: 1481857869104
Rationale for change

This card misleads into thinking that only Parkinson disease is characterized by lewy bodies, but it should also include Lewy body dementia to include both arms of the α-synucleinopathies

Source:
Amboss: "Alpha-synuclein: A protein mainly found in terminal axons and encoded by SNCA gene on chromosome 4. Excess alpha-synuclein can aggregate and deposit intracellularly, thereby forming Lewy bodies. These are associated with neurodegeneration and so-called α-synucleinopathies, e.g., Lewy body dementia or Parkinson disease."

https://next.amboss.com/us/article/C30qkf?q=synculein#Zcb1cadc64cd05225f284eb9896f25762

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#AK_Step1_v12::#AMBOSS::1Pa2dk #AK_Step2_v12::#SketchyNeurology::04_Movement_&_Neurodegenerative_Disorders::02_Disorders_of_Basal_Ganglia::01_Parkinson_Disease #AK_Step1_v12::#Low/HighYield::5-LowYield #AK_Step2_v12::#Resources_by_rotation::Neuro::uw::zanki #AK_Step2_v12::!Shelf::Neuro::no_dupes #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Neurology::Neuro_Pathology #AK_Step1_v12::#Bootcamp::Neurology::26_Dementia::02_Parkinson_Disease #AK_Step2_v12::#FirstAid::09_Neuro::12_Neurodegenerative_Disorders::08_Lewy_Body_Dementia::Extra #AK_Step2_v12::#OME::02_Neurology::03_Tremor #AK_Step1_v12::#OME_banner::Clinical::10_Neurology::03_Tremor #AK_Step2_v12::#AMBOSS::5L0iyg #AK_Step1_v12::#Osmosis::16_Neuro::06_Pathology_-_Movement_&_balance_disorders::01_Parkinsons_disease #AK_Step1_v12::#AMBOSS::aYaQnQ #AK_Step2_v12::#FirstAid::09_Neuro::13_Movement_Disorders::02_Parkinson_Disease_and_Parkinsonis #AK_Step1_v12::#NBME::18 #AK_Step2_v12::#B&B::10_Neuro::03_Movement_Disorders::01_Parkinson's_Disease #PANCE::EOR::Family_med #AK_Step1_v12::#UWorld::Step::6631 #AK_Step1_v12::^Systems::Neuro::Pathology #AK_Step1_v12::#Physeo::11_Pathology::05_Neuropathology_Pathology::05_Dementia_Degenerative_Disorders #AK_Step1_v12::#SketchyPath::13_Neuro::05_Neurodegenerative::02_Creutzfeldt-Jakob_Disease,_Parkinsons_Disease_&_Huntingtons_Disease #AK_Step1_v12::#AMBOSS::Ycanaj #AK_Step1_v12::#NBME::29 #AK_Step1_v12::#Pixorize::05_Neuroanatomy::12_Neurodegenerative_Diseases::05_Parkinson_Disease #PANCE::EOR::IM #AK_Other::Card_Features::Histology #AK_Step1_v12::#Pathoma::17_Neuro::07_Dementia_&_Degenerative_Disorders #AK_Step1_v12::#B&B::16_Neuro::05_Other_Neurology_Topics::08_Dementia::Extra #AK_Step2_v12::Original_decks::Zanki_Step_2::Neuro::UW_Neuro #AK_Step1_v12::#FirstAid::12_Neurology_and_Special_Senses::03_Pathology::19_Neurodegenerative_movement_disorders::*Parkinson_Disease #AK_Step1_v12::#B&B::16_Neuro::05_Other_Neurology_Topics::14_Parkinson_Disease