This update refines the explanation of CMV latency:
1/ Specifying CMV latency in progenitor and myeloid cells
2/ Clarification of CMV reactivation process:
- the update highlights how CMV reactivates: when infected CD34+ HPCs or CD14+ monocytes differentiate into mature myeloid cells, such as macrophages and dendritic cells
- this is an important distinction because CMV latency does not occur in fully differentiated macrophages per se, but rather in their progenitor states
3/ Strengthening contrast with EBV:
- the revised version emphasizes that T and B cells are NOT primary sites of CMV latency, supporting recent changes made to the card
- it explicitly contrasts CMV latency in myeloid lineage cells with EBV's well-established latency in B lymphocytes
sources:
- https://www.amboss.com/us/knowledge/cytomegalovirus-infection
- https://pubmed.ncbi.nlm.nih.gov/33177198/
- https://pubmed.ncbi.nlm.nih.gov/25147545/