Accepted at 9:07 p.m. Jan, 29, 2025 by Brian_BH
Author: pkaps01
Co-authors: Brian_BH
Related Note: 1554057289325
Rationale for change

The order is wrong the neural tube does form the CNS as pointed out by @hakimclara. However there's also a lot of thought behind this card that I want to outline as a reference for future suggestions that may come up with it.

It appears that within the ectoderm there are neural plate borders which border the neural plate (shocker haha). During neurulation the ectoderm overlying the notochord begins to furrow, forming a neural groove (from the neural plate) surrounded by two neural folds (from part of what was originally called the neural plate borders). The neural folds eventually fuse together forming the neural tube (note that the neural fold portion appears to be excluded from the neural tube its just that their fusion brings together the two edges of the neural plate which form the neural tube). The "leading edges" of the neural fold become neural crest cells which according to Kaplan, KA become elements of the PNS.

So technically, certain elements of the PNS originate from the neural folds because neural crest cells come from the folds during neural tube closure. But the primary MCAT sources refer to the neural crest cells specifically as what forms ELEMENTS of the PNS.

I originally thought that this card was maybe purposefully less specific by saying neural fold to encompass the entirety of the PNS rather than saying neural crest cells which the MCAT materials highlight as becoming only PARTS of the PNS. This decision would have to be deliberate/using some outside knowledge given that none of the primary MCAT sources from my understanding support the notion that the PNS in its entirety come from the neural fold. It is now apparent this isn't true though:

Content beyond the scope of the MCAT but relevant to the argument I'm making and approach we take with this card:
There are also ectodermal placodes which are separate from neural crest cells and form parts of the PNS. Notably, the neural crest and placodes are two distinct progenitor populations that arise at the border of the vertebrate neural plate. However, only part of the neural plate border forms the neural fold. "At the neural fold stage, neural crest markers and the pre-placodal region are finally distinct, with *******neural crest markers expressed in the neural folds and pre-placodal genes expressed slightly more laterally in the ectoderm**********."
https://pmc.ncbi.nlm.nih.gov/articles/PMC3972267/

Therefore saying the PNS derives from the neural fold is not any more democratic than taking the more specific approach offered by the MCAT books (saying the neural crest forms parts of the PNS) given that the entirety of the PNS does not originate from the neural folds.

This all creates issues with the wording of the card that is necessary regardless of whether or not we go with neural fold or neural crest cells explicitly. There should be some wording that suggests its elements of the PNS not the entire PNS since none of the primary MCAT materials from my understanding support the current wording. I'm not sure of what this wording should be though and would appreciate any ideas!


Kaplan Chapter 1.6 Development:

Notochord stimulates ectoderm to fold over, creating a neural tube topped with neural crest cells.
- neural tube becomes the CNS
- neural crest cells spread out throughout the body, differentiating into many different tissues.

Cells at the leading edge of the neural fold are called the neural crest, and will migrate throughout the body to form disparate tissues, including dorsal root ganglia, melanocytes (pigment-producing cells), and calcitonin-producing cells of the thyroid.

https://www.khanacademy.org/test-prep/mcat/cells/embryology/a/human-embryogenesis

The neural crest is sometimes called the fourth germ layer, because the cells that become the sympathetic and parasympathetic nervous systems, melanocytes, Schwann cells, even some of the bones and connective tissue of the face.

UWorld: QId: 404008 (4908855): Image of neurulation process.

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