Accepted
at 2:05 a.m. Nov, 01, 2023
by
Aaron
Author:
Aaron
Type of change:
Updated content
Rationale for change
Kinda a bad card as it could be answered with any of the systems PAN hits. Changed the card to test more specific knowlege of neuro symptoms. Also added to extra section. https://www.amboss.com/us/knowledge/Polyarteritis_nodosa
Add MM part with suggestion of “Mitch24”
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Extra
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Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy
Sketchy 2
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Sketchy Extra
Watch Large & Medium Vessel Vasculitides
Watch Large & Medium Vessel Vasculitides
Picmonic
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Pixorize
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Physeo
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OME
Additional Resources
Robbins:
Clinical Features
PAN is primarily a disease of young adults but can occur in all age groups. The clinical course typically is episodic, with long symptom-free intervals. The systemic findings—malaise, fever, and weight loss—are nonspecific, and the vascular involvement is widely scattered, so that the clinical manifestations can be varied and puzzling. A “classic” presentation involves some combination of rapidly accelerating hypertension due to renal artery involvement; abdominal pain and bloody stools caused by gastrointestinal lesions; diffuse muscular aches and pains; and peripheral neuritis, predominantly affecting motor nerves. Renal involvement often is prominent and is a major cause of death.
Untreated, PAN typically is fatal; however, with immunosuppression, 5-year survival is close to 80%. Relapse occurs in up to 25% of the cases, more often in non–HBV-associated cases than those that follow HBV infection. The latter have a better long-term prognosis.
One by one
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