Accepted at 2:04 a.m. Nov, 01, 2023 by Cameron
Author: jprasadh
Co-authors: Cameron
Related Note: 1478995038587
Rationale for change

previously rejected with no reason given, please re-review

Text Text
Extra
- Destroyed platelets release TXA2/ADP causing thrombocytopenia (mucosal bleeding, petechiae, ecchymoses)

- Hemosiderinuria is seen days after hemolysis, hemoglobinuria can lead to renal failure

- Predominantly intravascular, but can be extravascular (C3 fragments can act as opsonin)

- Venous thrombosis appears in unusual locations (portal, mesenteric, cerebral veins)

PNH urine (left):
Photo credit: Nakamura et al., CC BY 2.0, via BMC Journal of Medical Case Reports
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid

Sketchy

Watch Intravascular Hemolysis Overview & Paroxysmal Nocturnal Hemoglobinuria (PNH)
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Watch Intravascular Hemolytic Anemia: Non-MAHA DDx


Watch Upper Abdominal Pain DDx



Watch Approach to Hematuria
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Picmonic
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Pixorize
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Physeo

Bootcamp
Watch associated Bootcamp video - Normocytic Anemia: Paroxysmal Nocturnal Hemoglobinuria

Watch associated Bootcamp video - Complement Disorders
OME

Additional Resources
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#AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::04_Pathology::11_Intrinsic_hemolytic_anemias::*Paroxysmal_Nocturnal_Hemoglobinuria #AK_Step1_v12::^Other::^EXPN::MedBullets #AK_Step1_v12::#UWorld::COMLEX::25752 #AK_Step2_v12::#SketchyFM::01_Acute_Presentations::08_Genitourinary_Symptoms::02_Approach_To_Hematuria #AK_Step1_v12::#AMBOSS::KjaUYk #AK_Step1_v12::#Bootcamp::Immunology::08_Complement::03_Complement_Disorders #PANCE::EOR::PEDS #AK_Step2_v12::#UWorld::COMLEX::28076 #AK_Step1_v12::#B&B::11_Hematology::02_Red_Blood_Cells::03_Intrinsic_Hemolysis #AK_Step1_v12::#Pathoma::05_RBC::06_Normocytic_Anemias_with_Intravascular_Hemolysis #AK_Step1_v12::#AMBOSS::riafG4 #AK_Step2_v12::#AMBOSS::vf0AL2 #AK_Step1_v12::#UWorld::Step::11869 #AK_Step1_v12::#FirstAid::10_Hematology_and_Oncology::03_Physiology::02_Antiglobulin_test::*Pathologies #AK_Step2_v12::#SketchyIM::10_Gastroenterology::01_Approach_to_Abdominal_Pain::01_Upper_Abdominal_Pain_DDx #AK_Step1_v12::#FirstAid::02_Immunology::03_Immune_Responses::05_Complement_disorders::02_Complement_regulatory_protein_deficiencies::*Paroxysmal_Nocturnal_Hemoglobinuria #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::08_Hemolytic_Anemia_Intrinsic_Causes #AK_Step1_v12::#Physeo::^physeo_image_update #AK_Step2_v12::#UWorld::Step::2258 #AK_Step1_v12::#Physeo::08_Immunology::01_Immunology::05_Complement #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC #AK_Step2_v12::#SketchyIM::08_Hematology_&_Oncology::02_Anemia::05_Intravascular_Hemolytic_Anemia:_Non_MAHA_DDx #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::07_Normocytic_Anemia #AK_Step1_v12::^Other::^EXPN::BGedit #AK_Step1_v12::^Systems::HemeOnc::RBC #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::04_Normocytic_Anemia::04_Paroxysmal_Nocturnal_Hemoglobinuria !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-RBC #AK_Step1_v12::#SketchyPath::09_Blood_&_Coagulation::02_Normocytic_&_Macrocytic_Anemias::02_Intravascular_Hemolysis_Overiew_&_Paroxysmal_Nocturnal_Hemoglobinuria_(PNH) #AK_Other::Card_Features::Mnemonic #AK_Other::Card_Features::^One_By_One