Created at 6:02 p.m. Jan, 20, 2025
Author:
methaqualone
Type of change:
Content error
Rationale for change
AMBOSS states that for primary adrenal insufficiency, there is no increase in 11-deoxycortisol or cortisol levels, but there's an increase in CRH/ACTH. AMBOSS states that for secondary adrenal insufficiency, there's no increase in 11-deoxycortisol, cortisol, or CRH/ACTH levels.
https://next.amboss.com/us/article/Ug0bu2?q=metyrapone%20stimulation%20test#Z4a69842567348625359b02c3cb6bf949
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{{c1::Metyrapone::Drug}} inhibits glucocorticoid biosynthesis via inhibition of the enzyme {{c2::11β-hydroxylase}}
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*administration → decreased cortisol → loss of negative feedback on anterior pituitary → increased ACTH secretion



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