Accepted at 2:02 a.m. Nov, 01, 2023 by Ahmed7
Author: rshah050
Related Note: 1461984963965
Rationale for change

It's important to distinguish that PTU blocks 5' deiodinase, not thyroid deiodinase. 5' deiodinase inhibits t4 -> t3 peripherally whereas thyroid deiodinase blocks the recycling of mit and dit to Iodide and tyrosine.

Source:
"...[PTU] also blocks conversion of T4 to T3 in peripheral tissues..." - UpToDate Mechanism of Action section for PTU

The enzyme which catalyzes T4 -> T3 peripherally is 5' Deiodinase, not "deiodinase" or "thyroid deiodinase"

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