Accepted
at 11:04 p.m. Dec, 27, 2024
by
Brian_BH
Author:
pkaps01
Type of change:
Updated content
Rationale for change
Important to know protecting strategies.
Kaplan Chapter 5 Alcohols: In addition to making hydroxyl groups of alcohols into better leaving groups for nucleophilic substitution reactions, mesyl and tosyl groups can also serve as protecting groups when we do not want alcohols to react. These groups are protective in that they will not react with many of the other reagents that would attack alcohols, especially oxidizing agents. Thus, reacting an alcohol to form a mesylate or tosylate is sometimes performed before multistep reactions in which the desired products do not derive from the alcohol.
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