Accepted at 1:54 a.m. Nov, 01, 2023 by dollajas
Bulk Suggestion Bulk ID: shmuelsash/03.10.23-05:53PM
Author: shmuelsash
Related Note: 1514420310124 1
Rationale for change

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Resistance to colistin (polymyxin E) is encoded via the Mcr-1 gene which alters the structure of {{c1::lipid A}}
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- Lipid A is the cytotoxic component of LPS

- The altered lipid A has a much lower affinity for colistin, thus reducing activity

- Seen in E. coli, Klebsiella, Enterobacter, Salmonella enterica
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
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Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize


Physeo

Bootcamp
Watch associated Bootcamp video - Antibiotics: Fosfomycin, Daptomycin, and Polymyxins
OME

Additional Resources
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One by one
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Changed Tags
#AK_Step1_v12::#SketchyPharm::07_Antimicrobials::08_Retired_Lessons::01_Daptomycin_Old_Version::zanki_extra
#AK_Step1_v12::#Pixorize::04_Microbiology::01_Antibiotics/Antiparasitics::20_Polymyxins #AK_Step1_v12::#OME_banner #AK_Step1_v12::^Other::^HighYield::4-LowerYield #AK_Step1_v12::#FirstAid::03_Microbiology::07_Antimicrobials::24_Daptomycin #AK_Step1_v12::^Other::^FA_Updates::FA2018 #AK_Step1_v12::#Physeo::09_Pharm::05_Antibiotics::20_Daptomycin #AK_Step1_v12::^Other::^EXPN !AK_UpdateTags::Step1decks::Zanki-Pharmacology #AK_Step1_v12::#FirstAid::03_Microbiology::07_Antimicrobials::19_Polymyxins #AK_Step1_v12::#Physeo::09_Pharm::05_Antibiotics::17_Polymyxins #AK_Step1_v12::#Bootcamp::Microbiology::36_Antibiotics::21_Fosfomycin_Daptomycin_and_Polymyxins #AK_Original_Decks::Step_1::Zanki_Pharmacology #AK_Step1_v12::#Physeo::^physeo_image_update