Accepted at 6:49 p.m. Dec, 08, 2024 by Ahmed7
Author: mbaroody
Related Note: 1563496864933 1
Rationale for change

Additional context on hereditary angioedema, as well as C1 esterase inhibitor deficiency could help answer this question.

Here is a snippet from the answer explanation:

This patient's recurrent facial swelling is most likely due to hereditary angioedema, which is characterized by a deficiency or dysfunction of C1 inhibitor... Initial evaluation of hereditary angioedema is with complement testing. Low C4 is characteristic because, in the absence of C1 inhibitor, unregulated activation of C1 leads to excess activated C1 and, in turn, unchecked cleavage of C4.

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Pathoma
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Boards and Beyond
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Sketchy
Sketchy 2
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Sketchy Extra
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Changed Tags
#AK_Step1_v12::#UWorld::Step::20747
#AK_Step1_v12::!FLAG_THESE_CARDS::SketchyPathAdds #AK_Step1_v12::#SketchyPath::11_Immunology::02_Immunodeficiency::03_Complement_System_Disorders #AK_Step1_v12::^Systems::Immunology::JBadds #AK_Step1_v12::#Bootcamp::Immunology::08_Complement::03_Complement_Disorders #AK_Step2_v12::#UWorld::COMLEX::108149 #AK_Step1_v12::^Other::^EXPN::JBadd #PANCE::DERM::papulosquamous_disorders #AK_Step1_v12::#NBME::21 #AK_Step2_v12::#AMBOSS::9J0NwS #AK_Step2_v12::#UWorld::Step::20748 #AK_Step1_v12::#Low/HighYield::5-LowYield #AK_Other::!AK_UpdateTags::AnKing_Image::!Subjects::Biochemistry::Angioedema #AK_Step1_v12::#FirstAid::02_Immunology::03_Immune_Responses::05_Complement_disorders::02_Complement_regulatory_protein_deficiencies::*C1_Esterase_Inhibitor_Deficiency #AK_Step1_v12::#FirstAid::02_Immunology::03_Immune_Responses::05_Complement_disorders #AK_Step2_v12::#AMBOSS::lS0v-2 #AK_Step1_v12::#B&B::13_Immunology::01_Basic_Immunology::04_The_Complement_System #AK_Step1_v12::#AMBOSS::lS0v-2 #AK_Other::!AK_UpdateTags::AnKing_Image::Mujeeb::Angioedema #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Immunology_+_General_Pathology::Pathoma_Chapter_2_(Inflammation) #AK_Step2_v12::!Shelf::Peds #AK_Step1_v12::#OME::Clinical::Pediatrics::Pediatric_Subspecialties::Immunodeficiencies #PANCE::EOR::Family_med