Accepted at 2:38 p.m. Nov, 29, 2024 by Ahmed7
Author: Brian_BH
Related Note: 1471899395392
Rationale for change

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- Due to macrophage-mediated structural degradation

- Presents with sudden-onset pulmonary edema, hypotension, and a systolic murmur (cardiac apex)

- Ischemia → papillary muscle rupture → mitral regurgitation leading to pulmonary edema
*Posteromedial papillary muscle is supplied by the PDA (assuming right-dominant look for RCA infarct, ST elevations from leads II, III, and aVF can be seen)

Photo credit: Zorkun, CC BY-SA 3.0, via Wikidocs
TimelineComplicationExtra
Days to monthsArrhythmiaCommon cause of death post-MI
1-3 daysFibrinous pericarditisFriction rub
< 1 weekPapillary muscle rupturePosteromedial, mitral regurgitation
Interventricular wall ruptureVSD, ↑O2 sat in the RV
< 2 weeksVentricular pseudoaneurysmContained within the pericardium
Ventricular free wall ruptureCardiac tamponade
2 weeks - monthsTrue ventricular aneurysmContains all 3 layers
Dressler syndromeAutoimmune mediated fibrinous pericarditis
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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OME

Additional Resources

Papillary muscle rupture
Photograph of a heart at autopsy (close-up of the left ventricle in longitudinal section)
The posteromedial papillary muscle of the mitral valve has ruptured and almost completely detached from its ventricular attachment.
This is the characteristic appearance of papillary muscle rupture, a complication of myocardial infarction. The posteromedial papillary muscle is supplied by the posterior descending artery and is susceptible to ischemia and rupture in individuals with critical occlusion of this artery.


Ruptured papillary muscle
Photograph of a heart at autopsy (close-up of the left ventricle in longitudinal section)
The anterolateral papillary muscle of the mitral valve has avulsed from its ventricular attachment. The posteromedial papillary muscle is mostly intact, except for a small area of ischemic necrosis near its attachment to the chordae tendineae. The chordae tendineae are the white strings connecting the papillary muscles to the mitral valve.
This is the characteristic appearance of papillary muscle rupture, a complication of myocardial infarction.


→ acute onset of pulmonary edema, hypotension, dyspnea/tachypnea, and soft systolic murmur (MR)

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