Rejected at 4:32 a.m. Nov, 29, 2024 ] by andrewmathias8
Author: davidbaron
Related Note: 1461985304582
Rationale for change

organification is the addition of I2 into MIT or DIT. oxidation of iodine is the production of I2 from I-

amboss- Oxidation of iodide (I- → I2)
Organification of the generated I2 by covalently linking it with the tyrosine residues present in TG.
link: https://next.amboss.com/us/article/i60JkS?q=organification%20of%20iodine

Rejection reason

You're correct in your understanding of the difference between organification and oxidation, but I think you're misreading the card. The card is correct in its description of the Wolff-Chaikoff effect (inhibition of organification d/t too much iodine).

Text Text
Extra
- Inhibition occurs via transient inhibition of thyroid peroxidase

Can be manipulated to protect the thyroid when:
- Patients undergo imaging involving 131I (give potassium iodine beforehand to inhibit the incorporation of further iodine in thyroid)
- Concern for nuclear emergency prophylaxis

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Pathoma
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OME

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