Accepted at 1:25 a.m. Nov, 01, 2023 by dollajas
Author: AbdelrahmanMahmoud
Related Note: 1511028698049 1
Rationale for change

https://www.amboss.com/us/knowledge/Deep_vein_thrombosis

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- DOACs = Direct oral anticoagulants, which include direct factor Xa inhibitors (e.g., rivaroxaban, apixaban, or edoxaban) or direct thrombin inhibitors (e.g., dabigatran)

- Use UFH initially in patients with renal insufficiency or those at high risk of bleeding (can quickly turn off pump and / or reverse with protamine)

- None of the factor Xa or direct thrombin inhibitors require bridging or need to be overlapped, unlike warfarin (similar efficacy, lack of monitoring regular coagulation parameters, and no bridging requirement are a few reasons DOACs preferred over warfarin for long-term)

*Card previously said "LMWH bridge to warfarin," but more initial options exist and preference to DOACs over warfarin for the long-term has become the preference for nonpregnant patients (pregnant patients use LMWH long-term, or patients with active cancer)

- Real Life Pearl: Without insurance, DOACs cost about $100+ a month, while warfarin only costs $10 a month. Therefore, most uninsured patients end up on warfarin.
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
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Sketchy
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Sketchy 2




Watch Hypercoagulable Disorders DDx








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Watch Postoperative Surgical Fevers
Sketchy Extra
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Picmonic
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Bootcamp
Watch associated Bootcamp video - Coagulation and Fibrinolysis: Anticoagulation
OME

Additional Resources
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