Created at 10:22 p.m. Nov, 19, 2024
Author:
doc3g
Rationale for change
QID 119110 of Uworld for Step 3 covers this topic. Asks what the process for BRCA involves. Correct answer is DNA repair
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Text
In homologous recombination, dsDNA breaks are recognized by the {{c2::ATM}} protein and the {{c2::FA core}} complex, which activate {{c1::BRCA1/2}} to recruit enzymes to repair the break
Extra
Thus patients with BRCA1/2, FANC, ATM mutations are susceptible to damage by ionizing radiation


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Photo Credit: Hannes Lans, Jurgen A Marteijn and Wim Vermeulen, CC BY 2.0, via Wikimedia Commons
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy



Watch DNA Repair Mechanisms



Watch DNA Repair Mechanisms
Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - DNA Mutations, Damage, and Repair: Double Stranded Repair
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