Rejected at 4:10 p.m. Oct, 31, 2023 ] by Tahseen
Author: Joe
Related Note: 1476414676151
Rationale for change

Is this correct? MTHF is converted to DHF by thymidylate synthase and the DHF is in turn converted to THF by DHF reductase, but I can't find any external evidence that DHF is synthesised from folate using DHF reductase.

Sources:
https://en.wikipedia.org/wiki/Dihydrofolate_reductase

https://en.wikipedia.org/wiki/Dihydrofolic_acid

Rejection reason

Pathway exists. Why you're doing is reducing the folate which would add to hydrogens making it dihydrofolate. https://www.sciencedirect.com/topics/chemistry/dihydrofolate-reductase-inhibitor

Text Text
Extra
Lecture Notes
Empty field
Missed Questions
Empty field
Pathoma
Empty field
Boards and Beyond
Empty field
First Aid
Sketchy
Sketchy 2
Empty field
Sketchy Extra
Empty field
Picmonic
Empty field
Pixorize
Physeo
Empty field
Bootcamp
OME
Additional Resources
One by one
Empty field
#AK_Step1_v12::#FirstAid::01_Biochem::01_Molecular::03_De_novo_pyrimidine_and_purine_synthesis::*Folate_Metabolism #AK_Step2_v12::#B&B::07_Hematology_and_Oncology::01_Red_Cells::04_Macrocytic_Anemia::Extra #AK_Step1_v12::#B&B::04_Biochem::04_Vitamins::02_B12_and_Folate #AK_Step1_v12::#B&B::04_Biochem::01_Molecular::03_Pyrimidine_Metabolism::Extra #AK_Step1_v12::#Bootcamp::Biochemistry::12_Vitamins::13_Vitamin_B9_Folate #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step1_v12::#Bootcamp::Biochemistry::06_One_Carbon_Metabolism::01_Absorption_of_Folate #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step1_v12::#SketchyBiochem::03_Molecular_Biology::01_DNA::05_Purine_(De-Novo)_Pyrimidine_Synthesis #AK_Step1_v12::#Low/HighYield::1-HighYield #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::18_Purines_&_Pyrimidines #AK_Step1_v12::^Systems::Biochem::metabolism::protein #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::05_Macrocytic_Anemia::01_Folate_(Vitamin_B9)_Deficiency #AK_Step2_v12::#B&B::08_Infectious_Disease::01_Antibiotics::04_Other_Antibiotics #AK_Step1_v12::#Bootcamp::Microbiology::36_Antibiotics::19_Diaminopyrimidines_and_Sulfonamides #AK_Step1_v12::#NinjaNerd::03_Microbiology::04_Pharmacology::05_Antibiotics_(Folic_Acid_Pathway_Inhibitors:_Part_2) #AK_Step1_v12::#AMBOSS::a4aQ3k #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Biochemistry::Metabolism #AK_Step1_v12::#Pixorize::01_Biochemistry::02_Biochemical_Pathways::06_De_Novo_Pyrimidine_Synthesis