Accepted
at 3:48 p.m. Sep, 26, 2024
by
Ahmed7
Author:
drdave7
Type of change:
Updated content
Rationale for change
Outdated terminology
Source: Society Guidelines - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774468/
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Platelet dysfunction (uremic toxins interferes with platelet sticking)
Proposed mechanism
- ↑ Urea → arginine shunted to guanidinosuccinic acid (GSA), precursor to nitric oxide
- ↑ Nitric oxide → ↓ vWF secretion by endothelial cells → ↓ platelet adhesion
- ↑ Nitric oxide → ↓ ADP and TXA2 / ↓ activation of GplIb/Illa → ↓ platelet activation and aggregation
Proposed mechanism
- ↑ Urea → arginine shunted to guanidinosuccinic acid (GSA), precursor to nitric oxide
- ↑ Nitric oxide → ↓ vWF secretion by endothelial cells → ↓ platelet adhesion
- ↑ Nitric oxide → ↓ ADP and TXA2 / ↓ activation of GplIb/Illa → ↓ platelet activation and aggregation
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Watch Bleeding Disorders: Platelet Disorders DDx





Watch Bleeding Disorders: Coagulation Factor Disorders DDx
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