Accepted
at 5:49 p.m. Sep, 16, 2024
by
Ahmed7
Author:
beejumm
Type of change:
Updated content
Rationale for change
Added table based off Amboss's, paraphrased
Source: AMBOSS - https://next.amboss.com/us/article/mf0V52?q=hiv%20pregnancy#Zdf0b178f266d4cde23d0b5a6c001c470
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Additional Resources
The most important intervention for preventing the spread of HIV from mother to child is administration of combination antiretroviral therapy to the mother throughout pregnancy. Antiviral therapy should be initiated as soon as possible during pregnancy (even during the first trimester), regardless of maternal CD4 count or viral load. Antenatal combination therapy is the best way to suppress maternal HIV and prevent transplacental or perinatal acquisition by the infant. Mothers with undetectable viral loads at delivery have <1% risk of transmitting the infection to their infants. The 3-drug regimen should consist of 2 nucleoside reverse transcriptase inhibitors (NRTIs) plus a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor. An NRTI with good placental transfer (e.g. zidovudine, tenofovir) should be administered. Zidovudine should be administered to the neonate for >6 weeks.




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