Rejected
at 1:03 a.m. Sep, 15, 2024 ]
by
Cameron
Author:
mahiperla
Type of change:
Content error
Rationale for change
Source: First Aid 2024 pg 339 bottom table
17α-hydroxylase deficiency would cause increased aldosterone.
This card is actually about 11β-hydroxylase deficiency, which has decreased aldosterone but increased DOC leading to mineralocorticoid excess, as mentioned in the extra notes.
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Extra
*Increased levels of 11-deoxycorticosterone (DOC) and corticosterone cause mineralocorticoid excess, leading to renin inhibition (from hypertension), thus leading to decreased angiotensin II and aldosterone


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First Aid


Sketchy




Watch Congenital Adrenal Hyperplasia (CAH)
*Mistake in the Sketchy picture below: mineralocorticoid activity is elevated due to 11-deoxycorticosterone NOT aldosterone




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