Accepted
at 10:45 a.m. Sep, 15, 2024
by
Ahmed7
Author:
ashrafkotb
Type of change:
New Tags
Rationale for change
Putting a tag for molecular biochemistry on that fluoroquinolones card as the fluoroquinolones inhibit the topoisomerase II enzyme that take part in the DNA Replication process.
source: First Aid 2024 page 36 (DNA topoisomerases)
No changes in fields
Text
Which two enzymes are inhibited by fluoroquinolones?
{{c1::DNA topoisomerase II (Prokaryotic DNA gyrase), DNA topoisomerase IV}}
Extra
- "II, IV, hit the fluor" (fluoroquinolone antibiotics)
- Inhibit DNA replication, therefore are bactericidal
- Inhibit DNA replication, therefore are bactericidal
- Topoisomerase II introduces negative supercoils and opens DNA to expose DNA to replication enzymes
- Topoisomerase IV prevents sister chromatid from getting twisted and recombined
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - General Principles of Antibiotics
Watch associated Bootcamp video - Antibiotics: Fluoroquinolones
Watch associated Bootcamp video - Antibiotics: Fluoroquinolones
OME
Additional Resources
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