Multiple Myeloma is NOT a primary malignacy of the bone. It is called a plasmacytoma when it becomes a lesion that effects the bone, but I would still argue this is not a primary malignancy of bone as it is not primary because it does not originate in the bone. This card either needs to be updated as I have edited it or probably just removed.
Sources via AMBOSS definitions:
Plasma cell dyscrasia: a group of conditions characterized by the abnormal proliferation of the same type (=monoclonal) of a plasma cell that may also secrete a monoclonal immunoglobulin and/or immunoglobulin fragment (e.g., light chain)
Solitary plasmacytoma: an early-stage plasma cell dyscrasia characterized by a single lesion that affects bones (solitary plasmacytoma of bone) or soft tissue (solitary extramedullary plasmacytoma), or in rare cases multiple solitary lesions in soft tissue, bone or both (multiple solitary plasmacytoma)
Multiple myeloma: a malignant plasma cell dyscrasia characterized by uncontrolled proliferation and the diffuse infiltration of monoclonal plasma cells in the bone marrow
Stat pearls: Monoclonal Gammopathy of Undetermined Significance (MGUS)
Serum monoclonal protein less than 3 g/dl
Clonal bone marrow plasma cells less than 10%
No end-organ damage
Smoldering Multiple Myeloma
Monoclonal protein is greater than or equal to 3 g/dl
Clonal bone marrow plasma cells between 10% to 59%
No end-organ damage[22]
Solitary Plasmacytoma
Solitary lesion made up of clonal plasma cells
Normal bone marrow
Negative imaging outside of the single lesion
No end-organ damage
Case courtesy of Ashesh Ishwarlal Ranchod, Radiopaedia.org. From the case rID: 170092; modified by addition of overlays
Bone marrow particle largely replaced by sheets of neoplastic plasma cells:
Photo credit: ©️ Dr. Jian-Hua Qiao, all rights reserved, via Flickr (used with permission)
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