Created at 6:31 p.m. Jul, 17, 2024
Author: shashanktimilsina
Related Note: 1478898326485 1
Rationale for change

The card seems to be wrong as per AMBOSS. I have added in some important details in the Extra section.

Ref: AMBOSS
"Absorption
Stomach: Cobalamin is released from ingested proteins by pepsin and binds to the glycoprotein haptocorrin (R-protein), which protects it from gastric acid. [20]
Duodenum: Cobalamin is released from haptocorrin by trypsin and binds to intrinsic factor (IF), a protein produced by the parietal cells of the stomach that facilitates cobalamin absorption in the ileum.
Terminal ileum: cubilin receptor‐mediated endocytosis of the intrinsic factor-cobalamin complex → breakdown of IF in enterocytes, release of cobalamin, followed by binding to carrier protein transcobalamin II and then enters the plasma → cobalamin is either delivered to metabolically active tissues or stored in the liver"

https://www.amboss.com/us/knowledge/vitamins

Text Text
Extra Extra
Lecture Notes
Empty field
Missed Questions
Empty field
Pathoma
Empty field
Boards and Beyond
Empty field
First Aid


Sketchy
Empty field
Sketchy 2
Empty field
Sketchy Extra
Empty field
Picmonic
Empty field
Pixorize

Review Vitamin B12 (Cobalamin) Biochemistry
Physeo
Empty field
Bootcamp
Watch associated Bootcamp video - Macrocytic Anemia: Cobalamin (Vitamin B12) Deficiency
OME

Additional Resources
Other:

One by one
Empty field
!AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-RBC #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::10_Macrocytic_Anemia #AK_Step1_v12::#Pathoma::05_RBC::03_Macrocytic_Anemia #AK_Step1_v12::#FirstAid::09_Gastrointestinal::03_Physiology::06_Vitamin_and_mineral_absorption #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC #AK_Step1_v12::#Pixorize::01_Biochemistry::01_Vitamins::11_Vitamin_B12_(Cobalamin)_Biochemistry #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::05_Macrocytic_Anemia::02_Cobalamin_(Vitamin_B12)_Deficiency #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #PANCE::GI::nutrition #PANCE::HEME::cytopenias #AK_Step1_v12::^Systems::HemeOnc::RBC