Accepted at 4:22 p.m. Aug, 17, 2024 by Sameem
Author: Beaver4848
Co-authors: Ahmed7
Related Note: 1581533123500 1
Rationale for change

It is impossible to know whether this card is asking for iron deficiency or megaloblastic anemia as both are possible

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Watch Iron Deficiency Anemia & Anemia of Chronic Disease
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Watch associated Bootcamp video - Intestinal Pathology : Celiac Disease

Watch associated Bootcamp video - Microcytic Anemia : Iron Deficiency Anemia
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Additional Resources
Celiac disease etiopathogenesis
In patients with celiac disease, ingestion of gliadin, a component of gluten, leads to an immune response in the intestinal epithelium. Gliadin is deaminated by tissue transglutaminase (tTG) and then ingested by antigen-presenting cells (APC), which activate T cells via MHC II receptors. The activated T cell then activates plasma cells to release anti-tTG, antiendomysial, and antideaminated gliadin antibodies (which all function as diagnostic markers of celiac disease). T cells also differentiate into TH1 cells, which activate cytoplasmic fibroblasts to release matrix proteases. This leads to the destruction of the intestinal architecture with villus atrophy, crypt hyperplasia, and the loss of the brush border.

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