Rejected
at 7:09 a.m. Jun, 13, 2024 ]
by
Cameron
Author:
celembar
Type of change:
Updated content
Rationale for change
Can we change the verb "reduce" to "prevent" or something similar - reduce doesn't make as much sense here - a bit confusing
Rejection reason
Means the same thing; reduce the number of crises
Current
Suggested
Text
Text
Text
Text
Extra
- Hydroxyurea stimulates NO expression, which leads to a rise in cGMP which activates gamma-globin synthesis for HbF (which actively inhibits the polymerization of HbS)
Microvascular effects (from increased HbF):
↓ platelets/WBC → ↓ endothelial adhesion/activation → ↓ microparticles/thrombosis → ↓ vasoconstriction
Red blood cells effects (from increased HbF):
↑ HbF → ↓ HbS polymerization → ↓ RBC membrane damage → ↓ hemolysis → ↑ hemoglobin
- The end result is increased oxygenation to tissues and decreased inflammation
Microvascular effects (from increased HbF):
↓ platelets/WBC → ↓ endothelial adhesion/activation → ↓ microparticles/thrombosis → ↓ vasoconstriction
Red blood cells effects (from increased HbF):
↑ HbF → ↓ HbS polymerization → ↓ RBC membrane damage → ↓ hemolysis → ↑ hemoglobin
- The end result is increased oxygenation to tissues and decreased inflammation
Lecture Notes
Empty field
Missed Questions
Empty field
Pathoma
Empty field
Boards and Beyond
Empty field
First Aid




Sketchy 2
Empty field
Sketchy Extra
Empty field
Picmonic
Empty field
Pixorize


Physeo
Empty field
Bootcamp
Watch associated Bootcamp video - Blood Physiology: Hemoglobin
Watch associated Bootcamp video - Normocytic Anemia: Sickle Cell Anemia
Watch associated Bootcamp video - Cellular Injury and Neoplasia: Cell Cycle Dependent Drug Targets
Watch associated Bootcamp video - Principles of Oncology and Therapeutics: Cell Cycle Dependent Drug Targets
Watch associated Bootcamp video - DNA Structure : Clinical Applications of the Pyrimidine Pathway
Watch associated Bootcamp video - High Yield Genetic Disorders: Key Mutations: Cystic Fibrosis & Sickle Cell Anemia
Watch associated Bootcamp video - Normocytic Anemia: Sickle Cell Anemia
Watch associated Bootcamp video - Cellular Injury and Neoplasia: Cell Cycle Dependent Drug Targets
Watch associated Bootcamp video - Principles of Oncology and Therapeutics: Cell Cycle Dependent Drug Targets
Watch associated Bootcamp video - DNA Structure : Clinical Applications of the Pyrimidine Pathway
Watch associated Bootcamp video - High Yield Genetic Disorders: Key Mutations: Cystic Fibrosis & Sickle Cell Anemia
OME
Empty field
Additional Resources
One by one
Empty field






