Accepted at 4:11 p.m. May, 28, 2024 by IantheBFG
Author: IantheBFG
Co-authors: beejumm
Related Note: 1585694204080
Rationale for change

See this other suggestion

https://community.ankihub.net/t/05-20-2024-updated-content-anking-overhaul-for-step-1-2-ankingmed-id-1597722/226823/


https://next.amboss.com/us/article/fg0ku2?q=hyperpigmentation#Z9f44ec0e491e4c224e78db606ce019a4

"If secondary hypercortisolism: often hyperpigmentation (darkening of the skin due to an overproduction of melanin), especially in areas that are not normally exposed to the sun (e.g., palm creases, oral cavity)
Caused by excessive ACTH production because melanocyte-stimulating hormone (MSH) is cleaved from the same precursor as ACTH called proopiomelanocortin (POMC)
Not a feature of primary hypercortisolism"




AMBOSS states both Cushing disease and ectopic ACTH production e.g., SCLC will produce excess POMC that is cleaved into ACTH and MSH producing hyperpigmentation.

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#AK_Step1_v12::#Bootcamp::Endocrinology::06_Adrenal_Glands::06_Hypercortisolism_(Cushing_Syndrome) #AK_Step1_v12::#UWorld::COMLEX::26797 #AK_Step1_v12::#UWorld::Step::18801 #AK_Step1_v12::#Low/HighYield::1-HighYield #AK_Step2_v12::#SketchyIM::05_Endocrinology::04_Pituitary_&_Hypothalamic_Disorders::01_Hypopituitarism #AK_Step2_v12::#B&B::04_Endocrinology::02_Adrenal_Glands::02_Cushing_Syndrome::Extra #PANCE::ENDO::pituitary_disorders #AK_Other::SketchyPathAdds #AK_Other::^EXPN::JBadd #AK_Step1_v12::#UWorld::Step::15063 #AK_Step1_v12::#NinjaNerd::07_Endocrinology::02_Pathology::06_Cushing's_Syndrome_&_Disease #PANCE::EOR::IM #AK_Step1_v12::#OME::PreClinical::04_Organ_Systems::06_Endocrine::02_Adrenal::02_Cortisol #AK_Step2_v12::#SketchyIM::05_Endocrinology::04_Pituitary_&_Hypothalamic_Disorders::03_Pituitary_Adenoma #AK_Step1_v12::#AMBOSS::RXalBQ #AK_Step1_v12::#B&B::09_Endocrinology::02_Adrenals::02_Cushing_Syndrome #AK_Step2_v12::#SketchyIM::05_Endocrinology::03_Adrenal_Disorders::01_Cushing_Syndrome_SOAP #AK_Step1_v12::#FirstAid::08_Endocrine::04_Pathology::03_Hypopituitarism::*Causes::Pituitary_Adenoma::ACTH_Adenoma #AK_Step1_v12::#UWorld::COMLEX::26096 #AK_Step1_v12::#FirstAid::08_Endocrine::04_Pathology::19_Cushing_syndrome::*Presentation #AK_Step1_v12::#SketchyPath::07_Endocrine::02_Adrenal_Disorders::04_Cushings_Syndrome #AK_Other::#AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Endocrine::Endocrine_Pathology #PANCE::ENDO::adrenal_disorders #AK_Step1_v12::#B&B::09_Endocrinology::05_Other::01_Pituitary_Anatomy_and_Physiology #AK_Step1_v12::^Systems::Endocrine::JBadds #AK_Step1_v12::#Physeo::11_Pathology::02_Endocrine_Pathology::08_Hypercoritsolism #AK_Step1_v12::#OME::04_Organ_Systems::06_Endocrine::02_Adrenal::02_Cortisol