Rejected at 9:14 p.m. Apr, 30, 2024 ] by thomas.holmes
Author: oneMedGuy
Related Note: 1518401664461
Rationale for change

CA-125 is only seen in epithelial ovarian tumors. Germ cell tumors and sex cord-stromal tumors are not associated with it.

https://next.amboss.com/us/article/XF09g3?q=ovarian+tumors#puWLHM0

Rejection reason

See comments, better to keep this term broad

Text Text
Extra
- Mucin that advances tumorigenesis and proliferation by several mechanisms:

- Suppresses natural killer response

- Binds to mesothelin glycoprotein which is expressed mesothelial cells of the peritoneum (thus aiding in omental caking)

- Facilitates invasion by downregulating E-cadherin
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
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Sketchy

Watch Ovarian Cysts & Epithelial Ovarian Cancer
Sketchy 2
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Sketchy Extra
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Picmonic
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Pixorize
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Physeo
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Bootcamp
Watch associated Bootcamp video - Female Pathology: Ovarian Cancer Overview
OME

Additional Resources
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One by one
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#AK_Step1_v12::#AMBOSS #AK_Step1_v12::#UWorld::Step::1837 #AK_Step1_v12::#AMBOSS::1ba2sQ #AK_Step1_v12::^Other::^FA_Updates::FA2018 !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Immunology+General-Pathology::Pathoma-Chapter-3-(Neoplasia) #AK_Step1_v12::#UWorld::COMLEX::24946 #AK_Step1_v12::#Bootcamp::Reproduction::04_Female_Pathology::10_Ovarian_Cancer_Overview #AK_Step1_v12::#OME::02_The_Cell::03_Inflammation_Neoplasia::11_Diagnosing_Cancer #AK_Step1_v12::#SketchyPath::08_Repro_&_GU::02_Repro_Hormones_&_Ovarian_Disorders::03_Ovarian_Cysts_&_Epithelial_Ovarian_Cancer #AK_Step1_v12::^Other::^HighYield::1-HighYield #AK_Step1_v12::#Pathoma::13_Female::06_Ovarian_Tumors #AK_Step1_v12::#FirstAid::04_Pathology::03_Neoplasia::12_Serum_Tumor_Markers::CA-125 #AK_Step1_v12::#OME_banner::Basic_Science::07_Immunology #AK_Step1_v12::#Pathoma::03_Neoplasia::04_Clinical_Characteristics #AK_Step1_v12::#AMBOSS::PlaWCk #AK_Step1_v12::#B&B::20_Repro::04_Ovary::02_Ovarian_Epithelial_Tumors #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Immunology_+_General_Pathology::Pathoma_Chapter_3_(Neoplasia) #AK_Step1_v12::#Pathoma::03_Neoplasia_Alt_Tagging::BlueGalaxies::04_Clinical_Characteristics::Serum_Tumor_Markers #AK_Step1_v12::^Other::^EXPN::BGadd #AK_Step1_v12::#FirstAid::04_Pathology::03_Neoplasia::12_Serum_Tumor_Markers