Accepted
at 5:10 a.m. May, 01, 2024
by
musamalik
Author:
cpillu01
Co-authors:
herstein.jacob
Type of change:
Updated content
Rationale for change
Misaligned with Amboss (https://next.amboss.com/us/article/kT0mI2?q=polycythemia+vera):
98% of patients with polcythemia vera have a mutation in the JAK2 gene (gain of function) → ↑ tyrosine kinase activity → ***erythropoietin-independent proliferation*** of the myeloid cell lines → ↑ blood cell mass (erythrocytosis, thrombocytosis, and granulocytosis) → hyperviscosity and slow blood flow → ↑ risk of thrombosis and poor oxygenation.
And Robbins Pathologic Basis of Disease 10e....but no textbook references
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