Accepted
at 2:33 p.m. Oct, 02, 2023
Author:
spartandrew18
Type of change:
Updated content
Rationale for change
Helps know that there is 2 diseases.
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- In osteogenesis imperfecta; deficient type 1 collagen replaces glycine with a bulky amino acid, creating steric hindrance that prevents 3 pro-alpha chains from properly linking into the triple helix procollagen; This improper collagen structure is either destroyed in the fibroblast, or is faultily incorporated into bone with hydroxyapatite causing brittleness
- In scurvy, these patients can't hydroxylate pro-alpha chains (hydroxylation of proline or lysine requires vit C), thus they can't form the triple helix and the nascent collagen is degraded in the cell without being secreted

Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid




Sketchy 2
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Sketchy Extra
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Picmonic
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Physeo
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Bootcamp
Watch associated Bootcamp video - Connective Tissue: Collagen Synthesis
Watch associated Bootcamp video - Connective Tissue: Osteogenesis Imperfecta
Watch associated Bootcamp video - Connective Tissue: Osteogenesis Imperfecta
OME
Additional Resources
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One by one
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