Rejected at 1:09 p.m. Apr, 18, 2024 ] by Ahmed7
Author: christianphoward
Related Note: 1489961756380
Rationale for change

Per Amboss estrogen and progesterone inhibit GnRH release which in turn inhibits ovulation.

https://next.amboss.com/us/article/rt0fU3?utm_source=navbar&utm_medium=anki&utm_campaign=anki&utm_term=contraceptive&guid=r7oJ%257CWs5%2529r&aid=751067ab-c6e2-4e13-89fb-15ab1098e97c&uid=0nU2e7dSa#Z8f41cb91a5acc68fc5c04e73e600eea9

Rejection reason

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Extra
- Estrogen and progestins inhibit LH / FSH, thus preventing the estrogen surge / LH surge

- The hypothalamus has PR and ER receptors - allowing for negative feedback regulation of GnRH

- GnRH stimulates production of LH - which stimulates theca interna cells to produce progesterone and androstenedione, and FSH - which stimulates the production of 17β-estradiol
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Progestins also inhibit endometrial proliferation -> endometrium is less suitable to the implantation of an embryo.
Progestins cause thickening of cervical mucus, thereby limiting access of sperm to the uterus.
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