Accepted at 8:26 p.m. Apr, 03, 2024 by herstein.jacob
Author: Cameron
Related Note: 1476496102004
Rationale for change

QID is directly asking what is causing myelosuppression in this patient taking hydroxyurea. Knowing MOA of hydroxyurea is necessary to answer as the correct answer choice is "Medication-induced inhibition of NA synthesis enzyme"

Text
{{c1::Hydroxyurea}} inhibits {{c2::ribonucleotide reductase}}, which normally catalyzes conversion of UDP to dUDP (pyrimidine synthesis)
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Changed Tags
#AK_Step1_v12::#UWorld::19689
#AK_Step1_v12::#SketchyBiochem::03_Molecular_Biology::01_DNA::05_Purine_(De-Novo)_Pyrimidine_Synthesis #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Biochemistry::Metabolism #AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis::Pyrimidine_Synthesis::Hydroxyurea #AK_Step1_v12::#Pixorize::01_Biochemistry::02_Biochemical_Pathways::06_De_Novo_Pyrimidine_Synthesis #AK_Step1_v12::#Bootcamp::Genetics::01_DNA_Structure::04_Pyrimidine_Synthesis #AK_Step1_v12::#B&B::03_Biochem::01_Molecular::03_Pyrimidine_Metabolism #AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis::Pyrimidine_Synthesis::*Pyrimidine_Metabolism #AK_Step1_v12::#UWorld::COMLEX::27183 !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Biochemistry::Metabolism !AK_UpdateTags::^temporary::ImageFix::06::done #AK_Step1_v12::#UWorld::Step::19689 #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::18_Purines_&_Pyrimidines AnkiHub_ImageReady::Extra #AK_Step1_v12::^Systems::Biochem::metabolism::protein AnkiHub_ImageReady::Text #AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis #AK_Step1_v12::#OME::PreClinical::Biochemistry