Accepted at 8:26 p.m. Apr, 03, 2024 by herstein.jacob
Author: Cameron
Related Note: 1476496102004
Rationale for change

QID is directly asking what is causing myelosuppression in this patient taking hydroxyurea. Knowing MOA of hydroxyurea is necessary to answer as the correct answer choice is "Medication-induced inhibition of NA synthesis enzyme"

Text
{{c1::Hydroxyurea}} inhibits {{c2::ribonucleotide reductase}}, which normally catalyzes conversion of UDP to dUDP (pyrimidine synthesis)
Extra

Image licensed by Physeo and used with permission. Purchase full access here.
Lecture Notes
Empty field
Missed Questions
Empty field
Pathoma
Empty field
Boards and Beyond
Empty field
First Aid

Sketchy 2
Empty field
Sketchy Extra
Empty field
Picmonic
Empty field
Physeo
Empty field
OME

Additional Resources
One by one
Empty field
Changed Tags
#AK_Step1_v12::#UWorld::19689
#AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis::Pyrimidine_Synthesis::*Pyrimidine_Metabolism #AK_Step1_v12::#B&B::03_Biochem::01_Molecular::03_Pyrimidine_Metabolism #AK_Step1_v12::#UWorld::COMLEX::27183 #AK_Step1_v12::#Physeo::05_Biochem::05_Metabolism::18_Purines_&_Pyrimidines AnkiHub_ImageReady::Text AnkiHub_ImageReady::Extra #AK_Step1_v12::#UWorld::Step::19689 #AK_Step1_v12::#SketchyBiochem::03_Molecular_Biology::01_DNA::05_Purine_(De-Novo)_Pyrimidine_Synthesis #AK_Step1_v12::#OME_banner::Basic_Science::02_Metabolism #AK_Step1_v12::^Systems::Biochem::metabolism::protein #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Biochemistry::Metabolism #AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Biochemistry::Metabolism #AK_Step1_v12::#FirstAid::01_Biochemistry::01_Molecular::03_De_Novo_Pyrimidine_&_Purine_Synthesis::Pyrimidine_Synthesis::Hydroxyurea !AK_UpdateTags::^temporary::ImageFix::06::done #AK_Step1_v12::#Bootcamp::Genetics::01_DNA_Structure::04_Pyrimidine_Synthesis #AK_Step1_v12::#Pixorize::01_Biochemistry::02_Biochemical_Pathways::06_De_Novo_Pyrimidine_Synthesis