Accepted at 2:58 p.m. Mar, 23, 2024 by Cameron
Author: mohannadkh10
Related Note: 1478898326485 1
Rationale for change

R binder is produced in the stomach but the binding with B12 happens in the duodenum (with the action of trypsins)

Here is the text from amboss
"Absorption
Stomach: Cobalamin is released from ingested proteins by pepsin and binds to the glycoprotein haptocorrin (R-protein), which protects it from gastric acid. [20]
Duodenum: Cobalamin is released from haptocorrin by trypsin and binds to intrinsic factor (IF), a protein produced by the parietal cells of the stomach that facilitates cobalamin absorption in the ileum.
Terminal ileum: cubilin receptor‐mediated endocytosis of the intrinsic factor-cobalamin complex → breakdown of IF in enterocytes, release of cobalamin, followed by binding to carrier protein transcobalamin II and then enters the plasma → cobalamin is either delivered to metabolically active tissues or stored in the liver"
Source: AMBOSS - https://next.amboss.com/us/article/Ao0ReS?q=vitamin%20b12#MpcMJW0

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Text
{{c1::Salivary}} gland enzymes liberate vitamin B12 from animal-derived proteins
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Pixorize

Review Vitamin B12 (Cobalamin) Biochemistry
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Watch associated Bootcamp video - Macrocytic Anemia: Cobalamin (Vitamin B12) Deficiency
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#AK_Step1_v12::#FirstAid::09_Gastrointestinal::03_Physiology::06_Vitamin_and_mineral_absorption #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::05_Macrocytic_Anemia::02_Cobalamin_(Vitamin_B12)_Deficiency #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_RBC !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-RBC #PANCE::GI::nutrition #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::10_Macrocytic_Anemia #AK_Step1_v12::#OME::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #PANCE::HEME::cytopenias #AK_Step1_v12::#OME::Clinical::04_Organ_Systems::05_Hematology_Oncology::02_Anemia::06_Macrocytic_Anemia #AK_Step1_v12::#Pixorize::01_Biochemistry::01_Vitamins::11_Vitamin_B12_(Cobalamin)_Biochemistry #AK_Step1_v12::#Pathoma::05_RBC::03_Macrocytic_Anemia #AK_Step1_v12::^Systems::HemeOnc::RBC