Rejected
at 8:49 a.m. Mar, 29, 2024 ]
by
thomas.holmes
Author:
figeon
Type of change:
Content error
Rationale for change
UW ID 468. Explanation states that renal cell carcinoma CAN be bilateral, but is not necessary. The vignette also has a patient with a unilateral kidney mass. It is misleading to have this card emphasize bilateral in the mnemonic.
Rejection reason
see comments
Current
Suggested
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Extra
Hemangioblastomas are clumps of capillaries:
- High vascularity with hyperchromatic nuclei
- When occurs in the retina, can lead to retinal detachment, treat with argon laser phototherapy and cryotherapy if symptomatic
- Bright red on gross examination (well-circumscribed, benign, no invasion)
- Renal cell carcinomas are clear cell carcinomas, patients also develop renal cysts
- Pheochromocytomas manifest as excess adrenaline and tendency to be aggressive
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid
Sketchy
Sketchy 2
Watch Primary Brain Tumors in Adults
Watch Primary Brain Tumors in Adults
Sketchy Extra
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Picmonic
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Pixorize
Review von Hippel-Lindau (VHL)
Review von Hippel-Lindau (VHL)
Physeo
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Bootcamp
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OME
Additional Resources
Atlas:
Cerebellar hemangioblastoma
Cranial MRI (with contrast; axial view)
A brightly enhancing, sharply delimited nodular mass (white arrow) with nonenhancing, cystic areas is visible within the right cerebellar hemisphere.
These findings are consistent with cerebellar hemangioblastoma.
Hemangioblastomas of the CNS in Von-Hippel-Lindau syndrome
MRI imaging (contrast enhanced, T1w) in different planes
Image A (cranial MRI, axial view) shows a tumor within the lateral aspect of the right cerebellum. It consists of a hyperintense part and a larger, hypointense part, the latter indicating a fluid-filled cyst.
Image B (cranial MRI, sagittal view) shows a contrast-enhancing tumor between medulla oblongata and cerebellum, indicating a narrowing of foramen magnum.
Image C (spine MRI, sagittal view) shows a hyperintense tumor within the spinal canal at the level of vertebra C5-C6.
All of the hyperintense lesions are very likely to be vascular tumors (hemangiomas). The unusual, multiple occurrence within the CNS suggests a syndromal cause like Von-Hippel-Lindau syndrome. In this case, it can be assumed that the vascular tumors are hemangioblastomas.
Hemangioblastoma
Photomicrograph of cerebellar tissue (HPS stain; high magnification)
Numerous polygonal neoplastic stromal cells with lipid-laden vacuoles can be seen (examples indicated by green arrowheads), resulting in the typical clear-cell appearance. Additionally, there is an abundance of small, thin-walled blood vessels, many of them densely packed together (examples indicated by green overlay).
Diagnosis: cerebellar hemangioblastoma (WHO grade I)
Hemangioblastoma
Photomicrograph of a biopsy from a cerebellar mass (H&E stain)
Numerous thin-walled capillaries (examples in yellow overlay) containing erythrocytes (red, biconcave structures) are visible throughout the image.
Surrounding the capillaries are large stromal cells with multiple unstained intracytoplasmic lipid inclusions, which give them a foamy appearance (examples in blue overlay).
Surrounding the capillaries are large stromal cells with multiple unstained intracytoplasmic lipid inclusions, which give them a foamy appearance (examples in blue overlay).
This appearance is characteristic of hemangioblastoma.
Atlas:
One by one
y