Created at 4:11 p.m. Mar, 01, 2024
Author: musamalik
Related Note: 1474164950443 3
Rationale for change

This card needs clarification - according to ABMOSS, in 2 places amboss specifies extravascular for PKD and doesn't put it on the list for intravascular. However, other sources claim it does (assuming not as much): https://www.ncbi.nlm.nih.gov/books/NBK560581/

AMBOSS also doesn't say lack of ATP leads to extravascular hemolysis for other diseases such as spherocytosis (has other mechanisms) but outside sources say both play a role - don't think its boards relevant but i think the adding a qualifier word helps clarify

Source: AMBOSS - https://next.amboss.com/us/article/rT0fH2?q=pyruvate%20kinase%20deficiency%20hemolytic%20anemia#Z8c2a192c2270dcb9050dcc5cd2740211

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Sketchy



Watch Extravascular Hemolysis Overview & RBC Membrane Defects
Sketchy 2
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Review Pyruvate Kinase Deficiency
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Watch associated Bootcamp video - Pyruvate Kinase Deficiency

Watch associated Bootcamp video - Energy Production: Glycolysis: Key Substrates
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